MSDS

Material Safety Data Sheet

LIDOCAINE

SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - LIDOCAINE

SECTION 2. - - - - - COMPOSITION/INFORMATION - - - - -¬ CAS #: 137-58-6 C14H22N2O

SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - ¬ LABEL PRECAUTIONARY STATEMENTS TOXIC . TOXIC BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED. IRRITATING TO EYES, RESPIRATORY SYSTEM-AND SKIN. POSSIBLE RISK OF HARM TO THE UNBORN CHILD. CALIF. PROP. 65 REPRODUCTIVE HAZARD. POSSIBLE SENSITIZER. TARGET ORGAN(S): BLOOD IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE). IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF WATER AND SEEK MEDICAL ADVICE. -¬ WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYEIFACE PROTECTION. DO NOT BREATHE DUST. SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - -¬ IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A PHYSICIAN IMMEDIATELY. IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES. CALL A PHYSICIAN. IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING THE EYELIDS WITH FINGERS. CALL A PHYSICIAN. SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - ¬ EXTINGUISHING MEDIA WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM. SPECIAL FIREFIGHTING PROCEDURES WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND EYES. UNUSUAL FIRE AND EXPLOSIONS HAZARDS EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - -., - - -¬ WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. EVACUATE AREA.

SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - ¬ REFER TO SECTION 8.

SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - ¬ USE ONLY IN A CHEMICAL FUME HOOD. SAFETY SHOWER AND EYE BATH. WASH CONTAMINATED CLOTHING BEFORE REUSE. WASH THOROUGHLY AFTER HANDLING. DO NOT BREATHE DUST. DO NOT GET IN EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. NIOSH/MSHA-APPROVED RESPIRATOR. COMPATIBLE CHEMICAL-RESIST ANT GLOVES. CHEMICAL SAFETY GOGGLES. KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE.

SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - ¬ APPEARANCE AND ODOR SOLID. PHYSICAL PROPERTIES MELTING POINT: 138 - 140 C

SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - -¬ STABILITY STABLE. INCOMPATIBILITIES STRONG OXIDIZING AGENTS STRONG ACIDS STRONG BASES HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS CARBON MONOXIDE, CARBON DIOXIDE HAZARDOUS POLYMERIZATION WILL NOT OCCUR.

SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - ¬ ACUTE EFFECTS CAUSES SKIN IRRITATION. TOXIC IF ABSORBED THROUGH SKIN. CAUSES EYE IRRITATION. TOXIC IF INHALED. MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. TOXIC IF SWALLOWED. PROLONGED OR REPEATED EXPOSURE MAY CAUSE ALLERGIC REACTIONS IN CERT SENSITIVE INDIVIDUALS. TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. CHRONIC EFFECTS OVEREXPOSURE MAY CAUSE REPRODUCTIVE DISORDER(S) BASED ON TESTS WITH LABORATORY ANIMALS. TARGET ORGAN(S): BLOOD RTECS #: V00700000 SALICYLIC ACID, ACET ATE TOXICITY DATA ORL-CHD LDLO:I04 MG/KG UNR-MAN LDLO:294 MG/KG ORL-RAT LD50:200 MGIKG IPR-RAT LD50:340 MG/KG REC-RA T LD50:790 MG/KG ORL-MUS LD50:250 MG/KG IPR-MUS LDSO:167 MG/KG SCU-MUS LD50:1020 MG/KG UNR-MUS LD50:1350 MG/KG ORL-DOG LD50:700 MG/KG IVN-DOG LD50:681 MG/KG ORL-RBT LD50:101O MG/KG ORL-GPG LD50:1075 MG/KG ORL-HAM LD50:3500 MG/KG ORL-MAM LD50:1750 MG/KG TARGET ORGAN DATA SENSE ORGANS AND SPECIAL SENSES (TINNITUS) BEHAVIORAL (ALTERED SLEEP TIME) BEHAVIORAL (SOMNOLENCE) BEHAVIORAL (TREMOR) BEHAVIORAL (CHANGE IN MOTOR ACTIVITY) BEHAVIORAL (COMA) BEHAVIORAL (ANALGESIA) LUNGS, THORAX OR RESPIRATION (ACUTE PULMONARY EDEMA) LUNGS, THORAX OR RESPIRATION (RESPIRATORY DEPRESSION) LUNGS, THORAX OR RESPIRATION (RESPIRATORY STIMULATION) GASTROINTESTINAL (NAUSEA OR VOMITING) GASTROINTESTINAL (OTHER CHANGES) .LIVER (HEPATITIS: HEPA TOCELLULARNECROSIS, DIFFUSE) LIVER (LIVER FUNCTION TESTS IMP AIRED) KIDNEY, URETER, BLADDER (CHANGES IN TUBULES) KIDNEY, URETER, BLADDER (URINE VOLUME DECREASED OR ANURIA) LANCAO 2,809,1952 85DCAl2,73,1970 34ZIAG -,67,1969 NYKZAU 62,11,1966 34ZIAG -,67,1969 ARZNAD 5,572,1955 USXXAM #4376771 CPBTAL 28,1237,1980 USXXAM #5240918 ARZNAD 21,719,1971 AlPTAK 149,571,1964 GTPZAB 24(3),43,1980 JAPMA847,479,1958 ATSUDG 7,365,1984 IJMRAQ 81,621,1985 ¬ KIDNEY, URETER, BLADDER (HEMATURIA) BLOOD (HEMORRHAGE) MUSCULO-SKELETAL (OTHER CHANGES) PATERNAL EFFECTS (SPERMATOGENESIS) PATERNAL EFFECTS (TESTES, EPIDIDYMIS, SPERM DUCT) MATERNAL EFFECTS (MENSTRUAL CYLCE CHANGES OR DISORDERS) MATERNAL EFFECTS (PARTURITION) EFFECTS ON FERTILITY (PRE-IMPLANTATION MORTALITY) EFFECTS ON FERTILITY (POST-IMPLANTATION MORTALITY) EFFECTS ON FERTILITY (OTHER MEASURES OF FERTILITY) EFFECTS ON EMBRYO OR FETUS (EXTRA EMBRYONIC STRUCTURES) EFFECTS ON EMBRYO OR FETUS (FETOTOXICITY) EFFECTS ON EMBRYO OR FETUS (FETAL DEATH) EFFECTS ON EMBRYO OR FETUS (OTHER EFFECTS TO EMBYRO OR FETUS) SPECIFIC DEVELOPMENTAL ABNORMALITIES (CENTRAL NERVOUS SYSTEM) SPECIFIC DEVELOPMENTAL ABNORMALITIES (EYE, EAR) SPECIFIC DEVELOPMENTAL ABNORMALITIES (CRANIOFACIAL) SPECIFIC DEVELOPMENTAL ABNORMALITIES (BODY WALL) SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM) SPECIFIC DEVELOPMENTAL ABNORMALITIES (CARDIOVASCULAR SYSTEM) SPECIFIC DEVELOPMENTAL ABNORMALITIES (BLOOD AND LYMPHATIC SYSTEI SPECIFIC DEVELOPMENTAL ABNORMALITIES (OTHER DEVELOPMENTAL ABNO EFFECTS ON NEWBORN (STILLBIRTH) EFFECTS ON NEWBORN (LIVE BIRTH INDEX) EFFEC'fSeN-NEWBeRN-(0'f-HER-NEt)NA'f'At MEASURES OKEFFECTS) EFFECTS ON NEWBORN (BIOCHEMICAL AND METABOLIC) EFFECTS ON NEWBORN (OTHER POSTNATAL MEASURES OR EFFECTS) NUTRITIONAL AND GROSS METABOLIC (DEHYDRATION) NUTRITIONAL AND GROSS METABOLIC (BODY TEMPERATURE INCREASE) BIOCHEMICAL EFFECTS (OTHER) ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFORMATION.

SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - -¬ DATA NOT YET AVAILABLE.

SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - ¬ DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN J1I CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.

 SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - -¬ CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.

SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - -¬ EUROPEAN INFORMATION TOXIC R 23/24/25 TOXIC BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED R 36/37/38 IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN. R63 POSSIBLE RISK OF HARM TO THE UNBORN CHILD. S45 IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE' IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE). S 26 IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF WATER AND SEEK MEDICAL ADVICE. S 36/37/39 WEAR SUIT ABLE PROTECTIVE CLOTHING, GLOVES AND EYEIF ACE PROTECTION. . S 22 DO NOT BREATHE DUST. REVIEWS, STANDARDS, AND REGULATIONS OEL=MAK ACGIH TLV-TWA 5 MG/M3 DTLVS* TLV/BEI,1999 OEL-AUSTRALIA:TWA5 MG/M3 JAN 1993 OEL-AUSTRIA: MAK 5 MG/M3, JAN1999 OEL-BELGIUM:TW A 5 MG/M3 JAN 1993 OEL-DENMARK: TW A 5 MG/M3, JAN1999 OEL-THE NETHERLANDS:TWA 5 MG/M3 JAN 1993 OEL-RUSSIA:STEL 0.5 MG/M3 JAN 1993 - - -eEJ:;;SWITZBttl;AND:iWK5'MG/M3 IAN 1993 --¬ OEL-UNITED KINGDOM:TW A 5 MG/M3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA CHECK ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM CHECK ACGIH TL V NIOSH REL TO ACETYLSALICYLIC ACID-AlR:10H TW A 5 MG/M3 NIOSH* DHHS #92-100,1992 NOHS 1974: HZD 84517; NIS 12; TNF 1746; NOS 16; TNE 10452 NOES 1983: HZD X1189; NIS 1; TNF 27; NOS 1; TNE 191; TFE 82 NOES 1983: HZD 84517; NIS 9; TNF 491; NOS 22; TNE 10776; TFE 6083 EPA GENETOX PROGRAM 1988, NEGATIVE: SPERM MORPHOLOGY~MOUSE . EPA GENETOX PROGRAM 1988, INCONCLUSIVE: MAMMALIAN MICRONUCLEUS EPA TSCA SECTION 8(B) CHEMICAL INVENTORY EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, DECEMBER 1999 U.S. INFORMATION CALIFORNIA PROPOSITION 65: THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE FEMALE REPRODUCTIVE TOXICITY. THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE DEVELOPMENTAL TOXICITY.
SECTION 15. - - - - - - - - - OTHER INFORMATION - - - - - - - - - ¬ DISCLAIMER: THE INFORMATION, DATA, AND RECOMMENDATIONS ACCUMULATED HEREIN, AFTER REASONABLE INVESTIGATION AND RESEARCH, ARE BELIEVED TO BE ACCURATE BUT IS NOT WARRANTED TO BE WHETHER ORIGINATING WITH THE COMPANY OR NOT. RECIPIENTS ARE ADVISED TO CONFIRM IN ADVANCE OF NEED THAT THE INFORMATION IS CURRENT, APPLICABLE, AND SUIT ABLE TO THEIR CIRCUMSTANCES.